TOSIBAN
Atosiban from Zuventus
Atosiban ( Inj Tosiban 6.75 mg & 37.5 mg) by Zuventus is an inhibitor of the hormones oxytocin and vasopressin. Atosiban is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra).
Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels.
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Atosiban (Tosiban) Indication :
Atosiban is indicated to delay imminent pre-term birth in pregnant adult women with regular uterine contractions of at least 30 seconds duration at a rate of ≥4 per 30 minutes, cervical dilation of 1 to 3 cm (0–3 for nulliparas) and effacement of ≥50%.
Atosiban is also indicated to gestational age from 24 until 33 completed weeks & a normal foetal heart rate.
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